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产品目录

PI3 Kinase p110 Alpha/PIK3CA抗体图片
产品货号:
Z36729
中文名称:
PI3 Kinase p110 Alpha/PIK3CA抗体
英文名称:
Anti-PI3 Kinase p110 Alpha/PIK3CA Antibody (Clone#OTI7A7)
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-PI3 Kinase p110 Alpha/PIK3CA Antibody (Clone#OTI7A7)
指标别名p110 alpha;PI3 kinase subunit alpha;PI3K;PI3K alpha;PI3K p110(alpha);PIK3CA;PtdIns 3 kinase subunit alpha
克隆性Monoclonal
检验物种human,mouse,rat
应用范围IHC
基因名称PIK3CA
克隆号OTI7A7
抗体来源Mouse
抗体类型IgG2a
免疫原Human recombinant protein fragment corresponding to amino acids 303-631 of human PIK3CA (NP_006209) produced in E.coli.
实际分子量124.1KD
成分PBS (PH 7.3) containing 1% BSA,50% glycerol and 0.02% sodium azide.
纯化方式Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
浓度500μg/mL
产品形态溶液
保存条件Stable for 12 months from date of receipt.Store at -20℃ as received.
背景资料Phosphatidylinositol-4,5-bisphosphate 3-kinase,also called PIK3CA,is composed of an 85kDa regulatory subunit and a 110kDa catalytic subunit.PIK3CA gene is mapped to 3q26.32.The protein encoded by this gene represents the catalytic subunit,which uses ATP to phosphorylate phosphatidylinositols (PtdIns),PtdIns4P andPtdIns(4,5)P2.Recent evidence has shown that the PIK3CA gene is mutated in a range of human cancers.It has been found to be oncogenic and has been implicated in cervical cancers.PIK3CA mutations in breast cancer may be a predictive marker to guide the selection of patients who would benefit from mTOR inhibitor therapy.In addition to that,the presence of PIK3CA mutation may predict response to aspirin therapy for colorectal cancer,indicating power and promise of "Molecular Pathological Epidemiology (MPE)" approach as well as a complex interaction within the tumor microenvironment in this phenomenon.
Uniprot IDP42336
基因名全称phosphatidylinositol-4,5-bisphosphate 3-kinase,catalytic subunit alpha
蛋白名全称Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
推荐稀释比
Immunohistochemistry in paraffin section (IHC) 1:150

相关搜索:PI3 Kinase p110 Alpha/PIK3CA抗体PI3 Kinase p110 Alpha抗体PIK3CA单抗
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