产品货号：
Z36729
中文名称：
PI3 Kinase p110 Alpha/PIK3CA抗体
英文名称：
Anti-PI3 Kinase p110 Alpha/PIK3CA Antibody (Clone#OTI7A7)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PI3 Kinase p110 Alpha/PIK3CA Antibody (Clone#OTI7A7) |
| 指标别名 | p110 alpha;PI3 kinase subunit alpha;PI3K;PI3K alpha;PI3K p110(alpha);PIK3CA;PtdIns 3 kinase subunit alpha |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | IHC |
| 基因名称 | PIK3CA |
| 克隆号 | OTI7A7 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG2a |
| 免疫原 | Human recombinant protein fragment corresponding to amino acids 303-631 of human PIK3CA (NP_006209) produced in E.coli. |
| 实际分子量 | 124.1KD |
| 成分 | PBS (PH 7.3) containing 1% BSA,50% glycerol and 0.02% sodium azide. |
| 纯化方式 | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Stable for 12 months from date of receipt.Store at -20℃ as received. |
| 背景资料 | Phosphatidylinositol-4,5-bisphosphate 3-kinase,also called PIK3CA,is composed of an 85kDa regulatory subunit and a 110kDa catalytic subunit.PIK3CA gene is mapped to 3q26.32.The protein encoded by this gene represents the catalytic subunit,which uses ATP to phosphorylate phosphatidylinositols (PtdIns),PtdIns4P andPtdIns(4,5)P2.Recent evidence has shown that the PIK3CA gene is mutated in a range of human cancers.It has been found to be oncogenic and has been implicated in cervical cancers.PIK3CA mutations in breast cancer may be a predictive marker to guide the selection of patients who would benefit from mTOR inhibitor therapy.In addition to that,the presence of PIK3CA mutation may predict response to aspirin therapy for colorectal cancer,indicating power and promise of "Molecular Pathological Epidemiology (MPE)" approach as well as a complex interaction within the tumor microenvironment in this phenomenon. |
| Uniprot ID | P42336 |
| 基因名全称 | phosphatidylinositol-4,5-bisphosphate 3-kinase,catalytic subunit alpha |
| 蛋白名全称 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform |
| 推荐稀释比 | Immunohistochemistry in paraffin section (IHC) 1:150 |
相关搜索：PI3 Kinase p110 Alpha/PIK3CA抗体，PI3 Kinase p110 Alpha抗体，PIK3CA单抗